Egr-1 Enhances Drug Resistance of Breast Cancer Cells by MDR1 Dependence

Paclitaxel (PTX) is one of the most effective drugs used in treatment breast cancer. Nonetheless, appearance MDR1 (multidrug resistance 1) tumor cells has become a significant hindrance for efficacious chemotherapy. In this study, we show that expression level Egr-1 (early growth response gene-1) cancer tissues (from paclitaxel chemotherapy failure patients) and MCF-7/PTX (the cell line was resistant to paclitaxel) increased. Cell proliferation assay apoptosis revealed could promote inhibit MCF-7/PTX. Mechanistic studies indicated bind proximal promoter enhance transcription. These findings indicate induced accumulation upregulated MDR1, thereby inducing drug Our results suggest novel pathway by which induces expression, possibly illuminating potential target prevention MDR1-mediated resistance.